DISSECTING COMPLEX POLYKETIDE BIOSYNTHESIS

Dissecting complex polyketide biosynthesis

Numerous bioactive natural products are synthesised by modular polyketide synthases. These compounds can be made in high yield by native multienzyme assembly lines. However, formation of analogues by genetically engineered systems is often considerably less efficient. Biochemical studies on intact polyketide synthase proteins have amassed a body of knowledge that is substantial but still incomp...

Corrigendum to “Dissecting complex polyketide biosynthesis” [Comput Struct Biotechnol J 3(4) (2012) 1–8]

[This corrects the article DOI: 10.5936/csbj.201210010.].

The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases.

Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis. In modular PKSs, the polyketide chain is assembled by the successive condensation of activated carboxylic acid-derived units, where chain extension occurs with the intermediates remaining covalently boun...

The Stereochemistry of Complex Polyketide Biosynthesis

Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis. In modular PKSs, the polyketide chain is assembled by the successive condensation of activated carboxylic acid-derived units, where chain extension occurs with the intermediates remaining covalently boun...

Reactive Heterocycles for Examining Polyketide Biosynthesis